We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
TALENs: a widely applicable technology for targeted genome editing.
- Authors
Joung, J Keith; Sander, Jeffry D
- Abstract
Engineered nucleases enable the targeted alteration of nearly any gene in a wide range of cell types and organisms. The newly-developed transcription activator-like effector nucleases (TALENs) comprise a nonspecific DNA-cleaving nuclease fused to a DNA-binding domain that can be easily engineered so that TALENs can target essentially any sequence. The capability to quickly and efficiently alter genes using TALENs promises to have profound impacts on biological research and to yield potential therapeutic strategies for genetic diseases.
- Publication
Nature reviews. Molecular cell biology, 2013, Vol 14, Issue 1, p49
- ISSN
1471-0080
- Publication type
Journal Article
- DOI
10.1038/nrm3486