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- Title
Sirtuins as regulators of metabolism and healthspan.
- Authors
Houtkooper, Riekelt H; Pirinen, Eija; Auwerx, Johan
- Abstract
Since the beginning of the century, the mammalian sirtuin protein family (comprising SIRT1-SIRT7) has received much attention for its regulatory role, mainly in metabolism and ageing. Sirtuins act in different cellular compartments: they deacetylate histones and several transcriptional regulators in the nucleus, but also specific proteins in other cellular compartments, such as in the cytoplasm and in mitochondria. As a consequence, sirtuins regulate fat and glucose metabolism in response to physiological changes in energy levels, thereby acting as crucial regulators of the network that controls energy homeostasis and as such determines healthspan.
- Publication
Nature reviews. Molecular cell biology, 2012, Vol 13, Issue 4, p225
- ISSN
1471-0080
- Publication type
Journal Article
- DOI
10.1038/nrm3293