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- Title
The p53 family: guardians of maternal reproduction.
- Authors
Levine, Arnold J; Tomasini, Richard; McKeon, Frank D; Mak, Tak W; Melino, Gerry
- Abstract
The p53 family of proteins consists of p53, p63 and p73, which are transcription factors that affect both cancer and development. It is now emerging that these proteins also regulate maternal reproduction. Whereas p63 is important for maturation of the egg, p73 ensures normal mitosis in the developing blastocyst. p53 subsequently regulates implantation of the embryo through transcriptional control of leukaemia inhibitory factor. Elucidating the cell biological basis of how these factors regulate female fertility may lead to new approaches to the control of human maternal reproduction.
- Publication
Nature reviews. Molecular cell biology, 2011, Vol 12, Issue 4, p259
- ISSN
1471-0080
- Publication type
Journal Article
- DOI
10.1038/nrm3086