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- Title
Peroxisomal protein import and ERAD: variations on a common theme.
- Authors
Schliebs, Wolfgang; Girzalsky, Wolfgang; Erdmann, Ralf
- Abstract
Despite their distinct biological functions, there is a surprising similarity between the composition of the machinery that imports proteins into peroxisomes and the machinery that degrades endoplasmic reticulum (ER)-associated proteins. The basis of this similarity lies in the fact that both machineries make use of the same basic mechanistic principle: the tagging of a substrate by monoubiquitylation or polyubiquitylation and its subsequent recognition and ATP-dependent removal from a membrane by ATPases of the ATPases associated with diverse cellular activities (AAA) family of proteins. We propose that the ER-associated protein degradation (ERAD)-like removal of the peroxisomal import receptor is mechanically coupled to protein translocation into the organelle, giving rise to a new concept of export-driven import.
- Publication
Nature reviews. Molecular cell biology, 2010, Vol 11, Issue 12, p885
- ISSN
1471-0080
- Publication type
Journal Article
- DOI
10.1038/nrm3008