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- Title
Telomeres: protecting chromosomes against genome instability.
- Authors
O'Sullivan, Roderick J; Karlseder, Jan
- Abstract
The natural ends of linear chromosomes require unique genetic and structural adaptations to facilitate the protection of genetic material. This is achieved by the sequestration of the telomeric sequence into a protective nucleoprotein cap that masks the ends from constitutive exposure to the DNA damage response machinery. When telomeres are unmasked, genome instability arises. Balancing capping requirements with telomere replication and the enzymatic processing steps that are obligatory for telomere function is a complex problem. Telomeric proteins and their interacting factors create an environment at chromosome ends that inhibits DNA repair; however, the repair machinery is essential for proper telomere function.
- Publication
Nature reviews. Molecular cell biology, 2010, Vol 11, Issue 3, p171
- ISSN
1471-0080
- Publication type
Journal Article
- DOI
10.1038/nrm2848