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- Title
Integrins: masters and slaves of endocytic transport.
- Authors
Caswell, Patrick T; Vadrevu, Suryakiran; Norman, Jim C
- Abstract
Since it has become clear that adhesion receptors are trafficked through the endosomal pathway and that this can influence their function, much effort has been invested in obtaining detailed descriptions of the molecular machinery responsible for internalizing and recycling integrins. New findings indicate that integrin trafficking dictates the nature of Rho GTPase signalling during cytokinesis and cell migration. Furthermore, integrins can exert control over the trafficking of other receptors in a way that drives cancer cell invasion and tumour angiogenesis.
- Publication
Nature reviews. Molecular cell biology, 2009, Vol 10, Issue 12, p843
- ISSN
1471-0080
- Publication type
Journal Article
- DOI
10.1038/nrm2799