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- Title
An additional role for SUMO in ubiquitin-mediated proteolysis.
- Authors
Geoffroy, Marie-Claude; Hay, Ronald T
- Abstract
Although the post-translational modification of proteins with small ubiquitin-like modifier (SUMO) has a role in many biological processes, it was thought that SUMO, unlike ubiquitin, does not target proteins for degradation. However, these views need to be revised, as recent findings in yeast and human cells indicate that SUMO can act as a signal for the recruitment of E3 ubiquitin ligases, which leads to the ubiquitylation and degradation of the modified protein.
- Publication
Nature reviews. Molecular cell biology, 2009, Vol 10, Issue 8, p564
- ISSN
1471-0080
- Publication type
Journal Article
- DOI
10.1038/nrm2707