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- Title
β-Catenin hits chromatin: regulation of Wnt target gene activation.
- Authors
Mosimann, Christian; Hausmann, George; Basler, Konrad
- Abstract
The canonical Wnt pathway has gathered much attention in recent years owing to its fundamental contribution to metazoan development, tissue homeostasis and human malignancies. Wnt target gene transcription is regulated by nuclear β-catenin, and genetic assays have revealed various collaborating protein cofactors. Their daunting number and diverse nature, however, make it difficult to arrange an orderly picture of the nuclear Wnt transduction events. Yet, these findings emphasize that β-catenin-mediated transcription affects chromatin. How does β-catenin cope with chromatin regulation to turn on Wnt target genes?
- Publication
Nature Reviews Molecular Cell Biology, 2009, Vol 10, Issue 4, p276
- ISSN
1471-0072
- Publication type
Academic Journal
- DOI
10.1038/nrm2654