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- Title
MicroRNAs: key regulators of stem cells.
- Authors
Gangaraju, Vamsi K; Lin, Haifan
- Abstract
The hallmark of a stem cell is its ability to self-renew and to produce numerous differentiated cells. This unique property is controlled by dynamic interplays between extrinsic signalling, epigenetic, transcriptional and post-transcriptional regulations. Recent research indicates that microRNAs (miRNAs) have an important role in regulating stem cell self-renewal and differentiation by repressing the translation of selected mRNAs in stem cells and differentiating daughter cells. Such a role has been shown in embryonic stem cells, germline stem cells and various somatic tissue stem cells. These findings reveal a new dimension of gene regulation in controlling stem cell fate and behaviour.
- Publication
Nature reviews. Molecular cell biology, 2009, Vol 10, Issue 2, p116
- ISSN
1471-0080
- Publication type
Journal Article
- DOI
10.1038/nrm2621