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- Title
Is there a code embedded in proteins that is based on post-translational modifications?
- Authors
Sims, Robert J, 3rd; Reinberg, Danny
- Abstract
Covalent post-translational modifications (PTMs) provide vast indexing potential and expanded protein use. The 'histone code' hypothesis has inspired rapid advances throughout chromatin biology, and has recently been tapped for its relevance to non-histone proteins. Comprehensive analyses suggest that rather than constituting a general code, the covalent modifications of proteins (including histones) provide surfaces that are recognized by effectors that can give rise to intricate interactions and downstream events. These are reminiscent of other regulatory cascades in transcription and cell signalling.
- Publication
Nature reviews. Molecular cell biology, 2008, Vol 9, Issue 10, p815
- ISSN
1471-0080
- Publication type
Journal Article
- DOI
10.1038/nrm2502