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- Title
Endogenous small interfering RNAs in animals.
- Authors
Okamura, Katsutomo; Lai, Eric C
- Abstract
Until recently, only nematodes among animals had a well-defined endogenous small interfering RNA (endo-siRNA) pathway. This has changed dramatically with the recent discovery of diverse intramolecular and intermolecular substrates that generate endo-siRNAs in Drosophila melanogaster and mice. These findings suggest broad and possibly conserved roles for endogenous RNA interference in regulating host-gene expression and transposable element transcripts. They also raise many questions regarding the biogenesis and function of small regulatory RNAs in animals.
- Publication
Nature reviews. Molecular cell biology, 2008, Vol 9, Issue 9, p673
- ISSN
1471-0080
- Publication type
Journal Article
- DOI
10.1038/nrm2479