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- Title
ATR: an essential regulator of genome integrity.
- Authors
Cimprich, Karlene A; Cortez, David
- Abstract
Genome maintenance is a constant concern for cells, and a coordinated response to DNA damage is required to maintain cellular viability and prevent disease. The ataxia-telangiectasia mutated (ATM) and ATM and RAD3-related (ATR) protein kinases act as master regulators of the DNA-damage response by signalling to control cell-cycle transitions, DNA replication, DNA repair and apoptosis. Recent studies have provided new insights into the mechanisms that control ATR activation, have helped to explain the overlapping but non-redundant activities of ATR and ATM in DNA-damage signalling, and have clarified the crucial functions of ATR in maintaining genome integrity.
- Publication
Nature reviews. Molecular cell biology, 2008, Vol 9, Issue 8, p616
- ISSN
1471-0080
- Publication type
Journal Article
- DOI
10.1038/nrm2450