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- Title
Regulation of TNFR1 and CD95 signalling by receptor compartmentalization.
- Authors
Schütze, Stefan; Tchikov, Vladimir; Schneider-Brachert, Wulf
- Abstract
The death receptors tumour-necrosis factor receptor-1 (TNFR1) and CD95 (also known as FAS and APO-1) transduce signals that promote cell death by apoptosis. However, these receptors are also capable of inducing anti-apoptotic signals through the activation of the transcription factor nuclear factor-kappaB (NF-kappaB) or through activation of the proliferative mitogen-activated protein kinase (MAPK) cascade. Recent findings reveal a role for receptor internalization and endosomal trafficking in selectively transmitting the signals that lead either to apoptosis or to the survival of the cell.
- Publication
Nature reviews. Molecular cell biology, 2008, Vol 9, Issue 8, p655
- ISSN
1471-0080
- Publication type
Journal Article
- DOI
10.1038/nrm2430