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- Title
Tracking the ends: a dynamic protein network controls the fate of microtubule tips.
- Authors
Akhmanova, Anna; Steinmetz, Michel O
- Abstract
Microtubule plus-end tracking proteins (+TIPs) are a diverse group of evolutionarily conserved cellular factors that accumulate at the ends of growing microtubules. They form dynamic networks through the interaction of a limited set of protein modules, repeat sequences and linear motifs that bind to each other with moderate affinities. +TIPs regulate different aspects of cell architecture by controlling microtubule dynamics, microtubule interactions with cellular structures and signalling factors, and the forces that are exerted on microtubule networks.
- Publication
Nature reviews. Molecular cell biology, 2008, Vol 9, Issue 4, p309
- ISSN
1471-0080
- Publication type
Journal Article
- DOI
10.1038/nrm2369