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- Title
Small non-coding RNAs in animal development.
- Authors
Stefani, Giovanni; Slack, Frank J
- Abstract
The modulation of gene expression by small non-coding RNAs is a recently discovered level of gene regulation in animals and plants. In particular, microRNAs (miRNAs) and Piwi-interacting RNAs (piRNAs) have been implicated in various aspects of animal development, such as neuronal, muscle and germline development. During the past year, an improved understanding of the biological functions of small non-coding RNAs has been fostered by the analysis of genetic deletions of individual miRNAs in mammals. These studies show that miRNAs are key regulators of animal development and are potential human disease loci.
- Publication
Nature reviews. Molecular cell biology, 2008, Vol 9, Issue 3, p219
- ISSN
1471-0080
- Publication type
Journal Article
- DOI
10.1038/nrm2347