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- Title
Argonaute proteins: key players in RNA silencing.
- Authors
Hutvagner, Gyorgy; Simard, Martin J
- Abstract
During the past decade, small non-coding RNAs have rapidly emerged as important contributors to gene regulation. To carry out their biological functions, these small RNAs require a unique class of proteins called Argonautes. The discovery and our comprehension of this highly conserved protein family is closely linked to the study of RNA-based gene silencing mechanisms. With their functional domains, Argonaute proteins can bind small non-coding RNAs and control protein synthesis, affect messenger RNA stability and even participate in the production of a new class of small RNAs, Piwi-interacting RNAs.
- Publication
Nature reviews. Molecular cell biology, 2008, Vol 9, Issue 1, p22
- ISSN
1471-0080
- Publication type
Journal Article
- DOI
10.1038/nrm2321