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- Title
Cell evolution and the problem of membrane topology.
- Authors
Griffiths, Gareth
- Abstract
Cells somehow evolved from primordial chemistry and their emergence depended on the co-evolution of the cytoplasm, a genetic system and the cell membrane. It is widely believed that the cytoplasm evolved inside a primordial lipid vesicle, but here I argue that the earliest cytoplasm could have co-evolved to high complexity outside a vesicle on the membrane surface. An invagination of the membrane, aided by an early cytoskeletal system, may have formed the first cells--initially within primordial vesicles.
- Publication
Nature reviews. Molecular cell biology, 2007, Vol 8, Issue 12, p1018
- ISSN
1471-0080
- Publication type
Journal Article
- DOI
10.1038/nrm2287