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- Title
When cilia go bad: cilia defects and ciliopathies.
- Authors
Fliegauf, Manfred; Benzing, Thomas; Omran, Heymut
- Abstract
Defects in the function of cellular organelles such as peroxisomes, lysosomes and mitochondria are well-known causes of human diseases. Recently, another organelle has also been added to this list. Cilia--tiny hair-like organelles attached to the cell surface--are located on almost all polarized cell types of the human body and have been adapted as versatile tools for various cellular functions, explaining why cilia-related disorders can affect many organ systems. Several molecular mechanisms involved in cilia-related disorders have been identified that affect the structure and function of distinct cilia types.
- Publication
Nature reviews. Molecular cell biology, 2007, Vol 8, Issue 11, p880
- ISSN
1471-0080
- Publication type
Journal Article
- DOI
10.1038/nrm2278