We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease.
- Authors
Kun Ping Lu; Xiao Zhen Zhou
- Abstract
Protein phosphorylation regulates many cellular processes by causing changes in protein conformation. The prolyl isomerase PIN1 has been identified as a regulator of phosphorylation signalling that catalyses the conversion of specific phosphorylated motifs between the two completely distinct conformations in a subset of proteins. PIN1 regulates diverse cellular processes, including growth-signal responses, cell-cycle progression, cellular stress responses, neuronal function and immune responses. In line with the diverse physiological roles of PIN1, it has also been linked to several diseases that include cancer, Alzheimer's disease and asthma, and thus it might represent a novel therapeutic target.
- Publication
Nature Reviews Molecular Cell Biology, 2007, Vol 8, Issue 11, p904
- ISSN
1471-0072
- Publication type
Academic Journal
- DOI
10.1038/nrm2261