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- Title
The spindle-assembly checkpoint in space and time.
- Authors
Musacchio, Andrea; Salmon, Edward D
- Abstract
In eukaryotes, the spindle-assembly checkpoint (SAC) is a ubiquitous safety device that ensures the fidelity of chromosome segregation in mitosis. The SAC prevents chromosome mis-segregation and aneuploidy, and its dysfunction is implicated in tumorigenesis. Recent molecular analyses have begun to shed light on the complex interaction of the checkpoint proteins with kinetochores--structures that mediate the binding of spindle microtubules to chromosomes in mitosis. These studies are finally starting to reveal the mechanisms of checkpoint activation and silencing during mitotic progression.
- Publication
Nature reviews. Molecular cell biology, 2007, Vol 8, Issue 5, p379
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm2163