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- Title
Multiple levels of cyclin specificity in cell-cycle control.
- Authors
Bloom, Joanna; Cross, Frederick R
- Abstract
Cyclins regulate the cell cycle by binding to and activating cyclin-dependent kinases (Cdks). Phosphorylation of specific targets by cyclin-Cdk complexes sets in motion different processes that drive the cell cycle in a timely manner. In budding yeast, a single Cdk is activated by multiple cyclins. The ability of these cyclins to target specific proteins and to initiate different cell-cycle events might, in some cases, reflect the timing of the expression of the cyclins; in others, it might reflect intrinsic properties of the cyclins that render them better suited to target particular proteins.
- Publication
Nature reviews. Molecular cell biology, 2007, Vol 8, Issue 2, p149
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm2105