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- Title
Microtubule-organizing centres: a re-evaluation.
- Authors
Lüders, Jens; Stearns, Tim
- Abstract
The number, length, distribution and polarity of microtubules are largely controlled by microtubule-organizing centres, which nucleate and anchor microtubule minus ends in a process that requires gamma-tubulin. Here we discuss recent evidence indicating that gamma-tubulin-dependent formation of new microtubules is not restricted to conventional microtubule-organizing centres. These findings suggest that the spatio-temporal control of microtubule nucleation is more complex than previously thought, leading us to a re-evaluation of the concept of the microtubule-organizing center.
- Publication
Nature reviews. Molecular cell biology, 2007, Vol 8, Issue 2, p161
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm2100