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- Title
Functional and quantitative proteomics using SILAC.
- Authors
Mann, Matthias
- Abstract
Researchers in many biological areas now routinely characterize proteins by mass spectrometry. Among the many formats for quantitative proteomics, stable-isotope labelling by amino acids in cell culture (SILAC) has emerged as a simple and powerful one. SILAC removes false positives in protein-interaction studies, reveals large-scale kinetics of proteomes and - as a quantitative phosphoproteomics technology - directly uncovers important points in the signalling pathways that control cellular decisions.
- Publication
Nature reviews. Molecular cell biology, 2006, Vol 7, Issue 12, p952
- ISSN
1471-0072
- Publication type
Review
- DOI
10.1038/nrm2067