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- Title
Editor meets silencer: crosstalk between RNA editing and RNA interference.
- Authors
Nishikura, Kazuko
- Abstract
The most prevalent type of RNA editing is mediated by ADAR (adenosine deaminase acting on RNA) enzymes, which convert adenosines to inosines (a process known as A-->I RNA editing) in double-stranded (ds)RNA substrates. A-->I RNA editing was long thought to affect only selected transcripts by altering the proteins they encode. However, genome-wide screening has revealed numerous editing sites within inverted Alu repeats in introns and untranslated regions. Also, recent evidence indicates that A-->I RNA editing crosstalks with RNA-interference pathways, which, like A-->I RNA editing, involve dsRNAs. A-->I RNA editing therefore seems to have additional functions, including the regulation of retrotransposons and gene silencing, which adds a new urgency to the challenges of fully understanding ADAR functions.
- Publication
Nature reviews. Molecular cell biology, 2006, Vol 7, Issue 12, p919
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm2061