We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The anaphase promoting complex/cyclosome: a machine designed to destroy.
- Authors
Peters, Jan-Michael
- Abstract
The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has essential functions in and outside the eukaryotic cell cycle. It is the most complex molecular machine that is known to catalyse ubiquitylation reactions, and it contains more than a dozen subunits that assemble into a large 1.5-MDa complex. Recent discoveries have revealed an unexpected multitude of mechanisms that control APC/C activity, and have provided a first insight into how this unusual ubiquitin ligase recognizes its substrates.
- Publication
Nature reviews. Molecular cell biology, 2006, Vol 7, Issue 9, p644
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm1988