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- Title
Regulation of cardiac hypertrophy by intracellular signalling pathways.
- Authors
Heineke, Joerg; Molkentin, Jeffery D
- Abstract
The mammalian heart is a dynamic organ that can grow and change to accommodate alterations in its workload. During development and in response to physiological stimuli or pathological insults, the heart undergoes hypertrophic enlargement, which is characterized by an increase in the size of individual cardiac myocytes. Recent findings in genetically modified animal models implicate important intermediate signal-transduction pathways in the coordination of heart growth following physiological and pathological stimulation.
- Publication
Nature reviews. Molecular cell biology, 2006, Vol 7, Issue 8, p589
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm1983