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- Title
Chromatin remodelling: the industrial revolution of DNA around histones.
- Authors
Saha, Anjanabha; Wittmeyer, Jacqueline; Cairns, Bradley R
- Abstract
Chromatin remodellers are specialized multi-protein machines that enable access to nucleosomal DNA by altering the structure, composition and positioning of nucleosomes. All remodellers have a catalytic ATPase subunit that is similar to known DNA-translocating motor proteins, suggesting DNA translocation as a unifying aspect of their mechanism. Here, we explore the diversity and specialization of chromatin remodellers, discuss how nucleosome modifications regulate remodeller activity and consider a model for the exposure of nucleosomal DNA that involves the use of directional DNA translocation to pump 'DNA waves' around the nucleosome.
- Publication
Nature reviews. Molecular cell biology, 2006, Vol 7, Issue 6, p437
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm1945