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- Title
The multifaceted mismatch-repair system.
- Authors
Jiricny, Josef
- Abstract
By removing biosynthetic errors from newly synthesized DNA, mismatch repair (MMR) improves the fidelity of DNA replication by several orders of magnitude. Loss of MMR brings about a mutator phenotype, which causes a predisposition to cancer. But MMR status also affects meiotic and mitotic recombination, DNA-damage signalling, apoptosis and cell-type-specific processes such as class-switch recombination, somatic hypermutation and triplet-repeat expansion. This article reviews our current understanding of this multifaceted DNA-repair system in human cells.
- Publication
Nature reviews. Molecular cell biology, 2006, Vol 7, Issue 5, p335
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm1907