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- Title
Developmental apoptosis in C. elegans: a complex CEDnario.
- Authors
Lettre, Guillaume; Hengartner, Michael O
- Abstract
Apoptosis, an evolutionarily conserved programme of cellular self-destruction, is essential for the development and survival of most multicellular animals. It is required to ensure functional organ architecture and to maintain tissue homeostasis. During development of the simple nematode Caenorhabditis elegans, apoptosis claims over 10% of the somatic cells that are generated - these cells were healthy but unnecessary. Exciting insights into the regulation and execution of apoptosis in C. elegans have recently been made. These new findings will undoubtedly influence our perception of developmental apoptosis in more complex species, including humans.
- Publication
Nature reviews. Molecular cell biology, 2006, Vol 7, Issue 2, p97
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm1836