We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Semaphorins command cells to move.
- Authors
Kruger, Robert P; Aurandt, Jennifer; Guan, Kun-Liang
- Abstract
Semaphorins are secreted or transmembrane proteins that regulate cell motility and attachment in axon guidance, vascular growth, immune cell regulation and tumour progression. The main receptors for semaphorins are plexins, which have established roles in regulating Rho-family GTPases. Recent work shows that plexins can also influence R-Ras, which, in turn, can regulate integrins. Such regulation is probably a common feature of semaphorin signalling and contributes substantially to our understanding of semaphorin biology.
- Publication
Nature reviews. Molecular cell biology, 2005, Vol 6, Issue 10, p789
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm1740