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- Title
Proteomics of organelles and large cellular structures.
- Authors
Yates, John R, 3rd; Gilchrist, Annalyn; Howell, Kathryn E; Bergeron, John J M
- Abstract
The mass-spectrometry-based identification of proteins has created opportunities for the study of organelles, transport intermediates and large subcellular structures. Traditional cell-biology techniques are used to enrich these structures for proteomics analyses, and such analyses provide insights into the biology and functions of these structures. Here, we review the state-of-the-art proteomics techniques for the analysis of subcellular structures and discuss the biological insights that have been derived from such studies.
- Publication
Nature reviews. Molecular cell biology, 2005, Vol 6, Issue 9, p702
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm1711