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- Title
Ubiquitin and ubiquitin-like proteins as multifunctional signals.
- Authors
Welchman, Rebecca L; Gordon, Colin; Mayer, R John
- Abstract
Protein ubiquitylation is a recognized signal for protein degradation. However, it is increasingly realized that ubiquitin conjugation to proteins can be used for many other purposes. Furthermore, there are many ubiquitin-like proteins that control the activities of proteins. The central structural element of these post-translational modifications is the ubiquitin superfold. A common ancestor based on this superfold has evolved to give various proteins that are involved in diverse activities in the cell.
- Publication
Nature reviews. Molecular cell biology, 2005, Vol 6, Issue 8, p599
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm1700