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- Title
CLIPs and CLASPs and cellular dynamics.
- Authors
Galjart, Niels
- Abstract
The dynamic properties of microtubules are regulated by plus-end tracking proteins (+TIPs), which associate with the distal ends of microtubules. Among the +TIPs are cytoplasmic linker proteins (CLIPs), which promote microtubule growth and regulate dynein-dynactin localization, and CLIP-associating proteins (CLASPs), which stabilize specific subsets of microtubules on reception of signalling cues. CLIPs and CLASPs interact and cooperate to direct the microtubule network, thereby regulating cellular asymmetry.
- Publication
Nature reviews. Molecular cell biology, 2005, Vol 6, Issue 6, p487
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm1664