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- Title
Annexins: linking Ca<sup>2+</sup> signalling to membrane dynamics.
- Authors
Gerke, Volker; Creutz, Carl E.; Moss, Stephen E.
- Abstract
Eukaryotic cells contain various Ca2+-effector proteins that mediate cellular responses to changes in intracellular Ca2+ levels. A unique class of these proteins-annexins-can bind to certain membrane phospholipids in a Ca2+-dependent manner, providing a link between Ca2+ signalling and membrane functions. By forming networks on the membrane surface, annexins can function as organizers of membrane domains and membrane-recruitment platforms for proteins with which they interact. These and related properties enable annexins to participate in several otherwise unrelated events that range from membrane dynamics to cell differentiation and migration.
- Publication
Nature Reviews Molecular Cell Biology, 2005, Vol 6, Issue 6, p449
- ISSN
1471-0072
- Publication type
Academic Journal
- DOI
10.1038/nrm1661