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- Title
IAPs, RINGs and ubiquitylation.
- Authors
Vaux, David L; Silke, John
- Abstract
The inhibitor of apoptosis (IAP) proteins all contain one or more baculoviral IAP repeat motifs, through which they interact with various other proteins. Many IAPs also have another zinc-binding motif, the RING domain, which can recruit E2 ubiquitin-conjugating enzymes and catalyse the transfer of ubiquitin onto target proteins. The number of targets of IAP-mediated ubiquitylation is increasing and recent results indicate that outcomes following ubiquitylation are tantalizingly complex. As well as regulating other proteins, the IAPs themselves are controlled by ubiquitin-mediated degradation.
- Publication
Nature reviews. Molecular cell biology, 2005, Vol 6, Issue 4, p287
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm1621