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- Title
Intrinsically unstructured proteins and their functions.
- Authors
Dyson, H Jane; Wright, Peter E
- Abstract
Many gene sequences in eukaryotic genomes encode entire proteins or large segments of proteins that lack a well-structured three-dimensional fold. Disordered regions can be highly conserved between species in both composition and sequence and, contrary to the traditional view that protein function equates with a stable three-dimensional structure, disordered regions are often functional, in ways that we are only beginning to discover. Many disordered segments fold on binding to their biological targets (coupled folding and binding), whereas others constitute flexible linkers that have a role in the assembly of macromolecular arrays.
- Publication
Nature reviews. Molecular cell biology, 2005, Vol 6, Issue 3, p197
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm1589