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- Title
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors.
- Authors
Rossman, Kent L; Der, Channing J; Sondek, John
- Abstract
Guanine nucleotide-exchange factors (GEFs) are directly responsible for the activation of Rho-family GTPases in response to diverse extracellular stimuli, and ultimately regulate numerous cellular responses such as proliferation, differentiation and movement. With 69 distinct homologues, Dbl-related GEFs represent the largest family of direct activators of Rho GTPases in humans, and they activate Rho GTPases within particular spatio-temporal contexts. The failure to do so can have significant consequences and is reflected in the aberrant function of Dbl-family GEFs in some human diseases.
- Publication
Nature reviews. Molecular cell biology, 2005, Vol 6, Issue 2, p167
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm1587