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- Title
Focal adhesion kinase: in command and control of cell motility.
- Authors
Mitra, Satyajit K; Hanson, Daniel A; Schlaepfer, David D
- Abstract
A central question in cell biology is how membrane-spanning receptors transmit extracellular signals inside cells to modulate cell adhesion and motility. Focal adhesion kinase (FAK) is a crucial signalling component that is activated by numerous stimuli and functions as a biosensor or integrator to control cell motility. Through multifaceted and diverse molecular connections, FAK can influence the cytoskeleton, structures of cell adhesion sites and membrane protrusions to regulate cell movement.
- Publication
Nature reviews. Molecular cell biology, 2005, Vol 6, Issue 1, p56
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm1549