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- Title
Function and regulation of cullin-RING ubiquitin ligases.
- Authors
Petroski, Matthew D; Deshaies, Raymond J
- Abstract
Cullin-RING complexes comprise the largest known class of ubiquitin ligases. Owing to the great diversity of their substrate-receptor subunits, it is possible that there are hundreds of distinct cullin-RING ubiquitin ligases in eukaryotic cells, which establishes these enzymes as key mediators of post-translational protein regulation. In this review, we focus on the composition, regulation and function of cullin-RING ligases, and describe how these enzymes can be characterized by a set of general principles.
- Publication
Nature reviews. Molecular cell biology, 2005, Vol 6, Issue 1, p9
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm1547