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- Title
p53: traffic cop at the crossroads of DNA repair and recombination.
- Authors
Sengupta, Sagar; Harris, Curtis C
- Abstract
p53 mutants that lack DNA-binding activities, and therefore, transcriptional activities, are among the most common mutations in human cancer. Recently, a new role for p53 has come to light, as the tumour suppressor also functions in DNA repair and recombination. In cooperation with its function in transcription, the transcription-independent roles of p53 contribute to the control and efficiency of DNA repair and recombination.
- Publication
Nature reviews. Molecular cell biology, 2005, Vol 6, Issue 1, p44
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm1546