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- Title
Viral hijacking of G-protein-coupled-receptor signalling networks.
- Authors
Sodhi, Akrit; Montaner, Silvia; Gutkind, J Silvio
- Abstract
Viruses use a surprising diversity of approaches to hijack G-protein-coupled receptors and harness their activated intracellular signalling pathways. All of these approaches ultimately function to ensure viral replicative success and often contribute to their pathogenesis. Indeed, a single virus might deploy a repertoire of these strategies to regulate key intracellular survival, proliferative and chemotactic pathways. Understanding the contribution of these biochemical routes to viral pathogenesis might facilitate the development of effective target-specific therapeutic strategies against viral diseases.
- Publication
Nature reviews. Molecular cell biology, 2004, Vol 5, Issue 12, p998
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm1529