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- Title
The RAF proteins take centre stage.
- Authors
Wellbrock, Claudia; Karasarides, Maria; Marais, Richard
- Abstract
Since their discovery over 20 years ago, the RAF proteins have been intensely studied. For most of that time, the focus of the field has been the C-RAF isoform and its role as an effector of the RAS proteins. However, a report that implicates B-RAF in human cancer has highlighted the importance of all members of this protein kinase family and recent studies have uncovered intriguing new data relating to their complex regulation and biological functions.
- Publication
Nature reviews. Molecular cell biology, 2004, Vol 5, Issue 11, p875
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm1498