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- Title
Timeline: In search of the holy replicator.
- Authors
Gilbert, David M.
- Abstract
After 40 years of searching for the eukaryotic replicator sequence, it is time to abandon the concept of 'the' replicator as a single genetic entity. Here I propose a 'relaxed replicon model' in which a positive initiator-replicator interaction is facilitated by a combination of several complex features of chromatin. An important question for the future is whether the positions of replication origins are simply a passive result of local chromatin structure or are actively localized to coordinate replication with other chromosomal activities.
- Publication
Nature Reviews Molecular Cell Biology, 2004, Vol 5, Issue 10, p848
- ISSN
1471-0072
- Publication type
Academic Journal
- DOI
10.1038/nrm1495