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- Title
Opinion: The biogenesis of multivesicular endosomes.
- Authors
Gruenberg, Jean; Stenmark, Harald
- Abstract
Recent progress has been made in our understanding of the molecular mechanisms that regulate the biogenesis of multivesicular transport intermediates in the degradation pathway that leads to lysosomes. Here, we discuss recent work that uncovers some of the mechanisms that cause both membrane invagination within these newly forming intermediates and the detachment of these intermediates from early endosomal membranes.
- Publication
Nature Reviews Molecular Cell Biology, 2004, Vol 5, Issue 4, p317
- ISSN
1471-0072
- Publication type
Academic Journal
- DOI
10.1038/nrm1360