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- Title
Repairing DNA-methylation damage.
- Authors
Sedgwick, Barbara
- Abstract
Methylating agents modify DNA at many different sites, thereby producing lethal and mutagenic lesions. To remove all the main harmful base lesions, at least three types of DNA-repair activities can be used, each of which involves a different reaction mechanism. These activities include DNA-glycosylases, DNA-methyltransferases and the recently characterized DNA-dioxygenases. The Escherichia coli AlkB dioxygenase and the two human homologues, ABH2 and ABH3, represent a novel mechanism of DNA repair. They use iron-oxo intermediates to oxidize stable methylated bases in DNA and directly revert them to the unmodified form.
- Publication
Nature reviews. Molecular cell biology, 2004, Vol 5, Issue 2, p148
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm1312