We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Opinion: Epac: a new cAMP target and new avenues in cAMP research.
- Authors
Bos, Johannes L.
- Abstract
Five years ago, Epac - a guanine nucleotide exchange factor for the Ras-like small GTPases Rap1 and Rap2 - was found to be a new target of cyclic AMP, which opened up new avenues for cAMP research. Structural analysis of the cAMP-binding domains of Epac2 has identified a unifying mechanism for how cAMP activates proteins, and the design and synthesis of an Epac-specific cAMP analogue has paved the way for future discoveries.
- Publication
Nature Reviews Molecular Cell Biology, 2003, Vol 4, Issue 9, p733
- ISSN
1471-0072
- Publication type
Academic Journal
- DOI
10.1038/nrm1197