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- Title
Fibulins: a versatile family of extracellular matrix proteins.
- Authors
Timpl, Rupert; Sasaki, Takako; Kostka, Günter; Chu, Mon-Li
- Abstract
Fibulins are a newly recognized family of extracellular matrix proteins. The five known members of the family share an elongated structure and many calcium-binding sites, owing to the presence of tandem arrays of epidermal growth factor-like domains. They have overlapping binding sites for several basement-membrane proteins, tropoelastin, fibrillin, fibronectin and proteoglycans, and they participate in diverse supramolecular structures. New insights into their biological roles are now emerging from studies of transgenic mice and of some inherited human diseases.
- Publication
Nature reviews. Molecular cell biology, 2003, Vol 4, Issue 6, p479
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm1130