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- Title
Tor signalling in bugs, brain and brawn.
- Authors
Jacinto, Estela; Hall, Michael N
- Abstract
TOR--a highly conserved atypical protein kinase and the 'target of rapamycin', an immunosuppressant and anti-cancer drug--controls cell growth. TOR controls the growth of proliferating yeast, fly and mammalian cells in response to nutrients. Recent findings, however, indicate that TOR also controls the growth of non-proliferating cells, such as neurons and muscle cells. Furthermore, TOR, by associating with regulatory proteins and inhibiting phosphatases, controls the activity of multiphosphorylated effectors.
- Publication
Nature reviews. Molecular cell biology, 2003, Vol 4, Issue 2, p117
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm1018