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- Title
Transglutaminases: crosslinking enzymes with pleiotropic functions.
- Authors
Lorand, Laszlo; Graham, Robert M
- Abstract
Blood coagulation, skin-barrier formation, hardening of the fertilization envelope, extracellular-matrix assembly and other important biological processes are dependent on the rapid generation of covalent crosslinks between proteins. These reactions--which are catalysed by transglutaminases--endow the resulting supramolecular structure with extra rigidity and resistance against proteolytic degradation. Some transglutaminases function as molecular switches in cytoskeletal scaffolding and modulate protein-protein interactions. Having knowledge of these enzymes is essential for understanding the aetiologies of diverse hereditary diseases of the blood and skin, and various autoimmune, inflammatory and degenerative conditions.
- Publication
Nature reviews. Molecular cell biology, 2003, Vol 4, Issue 2, p140
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm1014