We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Alloreactive killer cells: hindrance and help for haematopoietic transplants.
- Authors
Parham, Peter; McQueen, Karina L
- Abstract
Haematopoietic-cell transplantation is a treatment for leukaemia and lymphoma. To reduce the incidence of graft-versus-host disease (GVHD) caused by transplanted T cells, donors and recipients are HLA matched. For patients for whom a matched donor is not available, one option is transplantation from an HLA-mismatched relative who shares one HLA haplotype. This procedure is distinguished by the use of a stronger conditioning regimen for the patient and of a T-cell-depleted graft containing numerous stem cells. After transplantation, natural killer cells are prevalent, and they can include alloreactive cells that kill tumour cells and prevent GVHD. The alloreactions seem to be determined by the mismatched HLA class I ligands and their killer-cell immunoglobulin-like receptors.
- Publication
Nature reviews. Immunology, 2003, Vol 3, Issue 2, p108
- ISSN
1474-1733
- Publication type
Journal Article
- DOI
10.1038/nri999